6533b85ffe1ef96bd12c24db

RESEARCH PRODUCT

Modulation of peroxisomes abundance by argan oil and lipopolysaccharides in acyl-CoA oxidase 1-deficient fibroblasts

Gérard LizardPierre AndreolettiJoseph VamecqSoufiane El KamouniRiad El KebbajJoseph GrestiHammam I. El HajjNorbert LatruffeBoubker NasserM'hammed Saïd El KebbajMustapha Cherkaoui-malki

subject

food.ingredientChemistryArgan oilPeroxisome ProliferationPeroxisomemedicine.diseaseCell biologyfoodPeroxisomal disordermedicineAcyl-CoA oxidaseACOX1AdrenoleukodystrophyPeroxisome proliferator-activated receptor alpha

description

Pseudo-neonatal adrenoleukodystrophy (P-NALD) is a neurodegenerative disorder caused by acyl-CoA oxidase 1 (ACOX1) deficiency with subsequent impairment of peroxisomal fatty acid β-oxidation, accumulation of very long chain fatty acids (VLCFAs) and strong reduction in peroxisome abundance. Increase in peroxisome number has been previously suggested to improve peroxisomal disorders, and in this perspective, the present work was aimed at exploring whether modulation of peroxisomes abundance could be achieved in P-NALD fibroblasts. Here we showed that treatment with the natural Argan oil induced peroxisome proliferation in P-NALD fibroblasts. This induction was independent on activations of both nuclear receptor PPARα and its coactivator PGC-1α. Lipopolysaccharides (LPS) treatment, which caused inflammation, induced also a peroxisome proliferation that, in contrast, was dependent on activations of PPARα and PGC-1α. By its ability to induce peroxisome proliferation, Argan oil is suggested to be of potential therapeutic use in patients with P-NALD.

yearjournalcountryeditionlanguage
2013-01-01Health
https://doi.org/10.4236/health.2013.51009