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RESEARCH PRODUCT

Growth of osteoblasts on lithographically modified surfaces

Sergey GorelickPaavo RahkilaA. Sagari A.r.Timo SajavaaraSulin ChengLennart B. KarlssonJeroen A. Van KanHarry J. Whitlow

subject

Nuclear and High Energy PhysicsMaterials scienceAspect ratio (aeronautics)Scanning electron microscopetechnology industry and agricultureNanotechnologyOsteoblastProton beam writinglaw.inventionmedicine.anatomical_structurelawOxygen plasmamedicineSurface layerPhotolithographyInstrumentationElectron-beam lithography

description

Here we report about preliminary investigations on developing substrates for culturing osteoblasts, the cells responsible for production of mineralised bone, by lithographically modifying the surfaces of several materials. The proton beam writing system at the National University of Singapore was used to fabricate high aspect ratio structures in PMMA, while two-dimensional low aspect ratio structures were fabricated using conventional electron beam lithography (EBL) and UV lithography (UVL) in SU-8. It was found that oxygen plasma treatment of structured SU-8 surfaces changed the surface layer and significantly improved cell attachment and proliferation. Cells grown on patterned thick PMMA exhibit a remarkable geometry-dependent behaviour.

yearjournalcountryeditionlanguage
2007-07-01Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
https://doi.org/10.1016/j.nimb.2007.02.008