6533b860fe1ef96bd12c3060
RESEARCH PRODUCT
Cytotoxicity of Secondary Metabolites from Dracaena viridiflora Engl & Krause and their Semisynthetic Analogues
Ulrich KauhlLéon Azefack TapondjouLouis P. SandjoRaymond Ngansop NonoRémy Bertrand TeponnoJean Paul DzoyemUdo BakowskyTill Opatzsubject
Pharmacologysteroidal saponinsbiologyTraditional medicine010405 organic chemistryChemistryOrganic ChemistryPlant Sciencebiology.organism_classification01 natural sciencesDracaena viridifloralcsh:QK1-9890104 chemical scienceslcsh:Chemistrylcsh:QD241-441010404 medicinal & biomolecular chemistrylcsh:QD1-999lcsh:Organic chemistryepoxycholesta-5.22-dieneslcsh:BotanyDrug DiscoverycytotoxicityCytotoxicityDracaenadescription
The MeOH extract of Dracaena viridiflora was found to display significant cytotoxicity against some cancer cell lines. Systematic phytochemical investigation of this extract led to the isolation and structure elucidation of ten secondary metabolites including five spirostane (1-5) and one furostane (6) steroidal saponins. Furthermore, some acetylated spirostane analogues and three previously unreported derivatives with the 22,26-epoxycholesta-5,22-diene skeleton (15-17) were prepared from trillin (1), prosapogenin A of dioscin (2) and dioscin (4) by reaction with ZnCl 2/Ac 2O. Among the isolated and semisynthetic compounds, dioscin showed the most potent cytotoxicity against A549, Jurkat and Skov-3 cells with IC 50 values of 0.42, 1.70 and 1.90 µg/mL, respectively. It was noteworthy that acetylation of the bioactive compounds led to semisynthetic derivatives which unfortunately did not present any activity. This is the first report on the phytochemical and pharmacological investigation of Dracaena viridiflora.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-06-14 | Records of Natural Products |