6533b860fe1ef96bd12c317a
RESEARCH PRODUCT
The nACHR4 594C/T polymorphism in Alzheimer disease
Matteo BulatiSalvo VitelloMaria Paola GrimaldiDomenico LioAlessandra AquinoCandoregiuseppinaRainer BarbieriSonya VastoVito DittaBalistrericarmela RitaCalogero CarusoGiuseppina Colonna-romanosubject
MaleNEURONAL NICOTINIC RECEPTORSAgingPopulationReceptors NicotinicBiologyBioinformaticsCHOLINERGIC HYPOTHESISNeurochemicalGene FrequencyAlzheimer DiseasemedicineGenetic predispositionHumansDementiaGenetic Predisposition to DiseaseBRAINeducationCognitive deficitAgedAged 80 and overGeneticseducation.field_of_studyPolymorphism GeneticMiddle Agedmedicine.diseaseGENENicotinic acetylcholine receptorCholinergicFemaleGeriatrics and Gerontologymedicine.symptomAlzheimer's diseasedescription
Alzheimer disease (AD) is the most common form of dementia with complex etiology and multifactorial origin. Although several neurochemical deficits have been described in AD patients, explanation of the nature of the cognitive disturbance is focused on the "cholinergic hypothesis." The neuronal nicotinic acetylcholine receptor (neuronal nAChR) belongs to the superfamily of ionic channel activated by ligand. This paper presents a population-based population association study, testing the hypothesis that variants of the nAChR gene confer genetic susceptibility to AD. The authors analyzed two cohorts constituted by 60 controls and 80 AD patients in which significant increase of 594T polymorphism in patients affected by AD versus controls was found. However, further studies are necessary to confirm this polymorphism trend and to establish the polymorphism functionality and its correlation with behavioral and cognitive deficit.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-03-01 |