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RESEARCH PRODUCT

Antimykotische wirkstoffe. XV. . Die halogensubstitution bei phenoxy-1,3,5-triazinen

Alfred KreutzbergerB. Richter

subject

NucleophileChemistryOrganic ChemistryPolymer chemistryChlorine atomSubstitution (logic)Nucleophilic substitution

description

Durch die nucleophile substitution eines Chloratoms in 2, 4-Dichloro-6-diethylamino-1, 3, 5-triazine (1) mittels Halogenphenolen (2a-f) werden die 2-chloro-4-diethylamino-6-halogenphenoxy-1, 3, 5-triazine (3a-f) zuganglich. In Strukturtyp 3 finden sich Vertreter mit antimykotischer Wirksamkeit. Through the nucleophilic substitution of one chlorine atom in 2,4-dichloro-6-diethylamino-1,3,5-triazine (1) by halophenols (2a-f) the 2-chloro-4-diethylamino-6-halophenoxy-1,3,5-triazines (3a-f) are accessible. Structure 3 comprises representatives exhibiting antimycotic activity.

yearjournalcountryeditionlanguage
1983-03-01Journal of Heterocyclic Chemistry
https://doi.org/10.1002/jhet.5570200214