6533b860fe1ef96bd12c3901

RESEARCH PRODUCT

Adalimumab for treatment of moderate to severe psoriasis and psoriatic arthritis

Spyridoula DoukakiMaria Rita BongiornoGiuseppe PistoneMaurizio Aricò

subject

AdultMalemedicine.medical_specialtyAnti-Inflammatory AgentsArthritisDermatologyAntibodies Monoclonal HumanizedSeverity of Illness IndexPsoriasis Psoriatic ArthritisPsoriatic arthritisPsoriasisSeverity of illnessSettore MED/35 - Malattie Cutanee E VenereemedicineAdalimumabHumansPsoriasisAdverse effectTumor Necrosis Factor-alphabusiness.industryArthritis PsoriaticAdalimumabAntibodies MonoclonalGeneral MedicineMiddle Agedmedicine.diseaseDermatologyRadiographyClinical trialTreatment OutcomeMonoclonalFemalebusinessmedicine.drug

description

Psoriasis and psoriatic arthritis are common diseases associated with considerable morbidity and disability. Their pathophysiology comprises similar processes leading to inflammation of skin, entheses, and joints. Although traditional systemic agents can be effective, their use may be limited by lack of efficacy and concerns regarding adverse effects. The objective of this study was to assess the efficacy and safety of adalimumab, a fully human antitumor necrosis factor (anti-TNF) monoclonal antibody, over 16 weeks. The present authors report their personal experience in 15 patients with severe plaque psoriasis and psoriatic arthritis, refractory to other treatments, in which a decisive regression of joint/skin involvement was obtained. Psoriasis and psoriatic arthritis are chronic inflammatory disorders resulting from a combination of genetic and environmental factors.

yearjournalcountryeditionlanguage
2008-09-01Dermatologic Therapy
https://doi.org/10.1111/j.1529-8019.2008.00227.x