6533b860fe1ef96bd12c3924

RESEARCH PRODUCT

Revisiting CD8 T-cell ‘Memory Inflation’: New Insights with Implications for Cytomegaloviruses as Vaccine Vectors

Rafaela HoltappelsSara BeckerKirsten FreitagAngélique RenzahoNiels A W LemmermannMatthias J. Reddehase

subject

KLRG10301 basic medicinecentral memory CD8 T cells (TCM)vaccine vectorHigh avidityImmunologylcsh:MedicineBiologyArticleEpitope03 medical and health sciences0302 clinical medicineImmune systemDrug DiscoveryCytotoxic T cellPharmacology (medical)Aviditycytomegalovirusmemory inflationPharmacologyeffector memory CD8 T cells (TEM)Human studiesEffectoravidity maturationlcsh:RVirology030104 developmental biologyInfectious Diseasesconventional TEM (cTEM)CD8inflationary TEM (iTEM)030215 immunology

description

Murine models of cytomegalovirus (CMV) infection have revealed an exceptional kinetics of the immune response. After resolution of productive infection, transient contraction of the viral epitope-specific CD8 T-cell pool was found to be followed by a pool expansion specific for certain viral epitopes during non-productive &lsquo

yearjournalcountryeditionlanguage
2020-07-22Vaccines
10.3390/vaccines8030402https://www.mdpi.com/2076-393X/8/3/402