6533b861fe1ef96bd12c4db3

RESEARCH PRODUCT

Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity

Céline MartinDéborah AncelPatricia Passilly-degraceMichael ChevrotSteven M. SparksPhilippe BesnardDaniel J. Drucker

subject

CD36 Antigensmedicine.medical_specialtyTasteendocrine systemCD36Blotting WesternQD415-436eating behaviorReal-Time Polymerase Chain ReactionBiochemistryGlucagon-Like Peptide-1 ReceptorReceptors G-Protein-CoupledMiceEndocrinologyTAS1R3TAS1R2Glucagon-Like Peptide 1Cell Line TumorInternal medicinelong-chain fatty acidReceptors GlucagonmedicineAnimalsHumansSecretionObesityReceptorLingual papillaResearch Articlesbiologydigestive oral and skin physiologyGPR120healthCell BiologyTaste BudsImmunohistochemistryMice Inbred C57BLEndocrinologyobesity riskbiology.protein

description

Glucagon-like peptide-1 (GLP-1) signaling modulates sweet-taste sensitivity in the mouse. Because circumvallate papillae (CVPs) express both GLP-1 and its receptor, a local regulation has been suggested. However, whether dietary lipids are involved in this regulation, as shown in the gut, is unknown. By using a combination of biochemical, immunohistochemical, and behavioral approaches, the present data i) confirm the role of GLP-1 signaling in the attraction for sucrose, ii) demonstrate that minute quantities of long-chain FAs (LCFAs) reinforce the attraction for sucrose in a GLP-1 receptor-dependent manner, iii) suggest an involvement of the LCFA receptor GPR120 expressed in taste buds in this system, and iv) support the existence of a regulation by GLP-1 of the lipid sensing mediated by lingual CD36. Therefore, oro-sensory detection of LCFAs may affect sweet and fatty taste responsiveness by controlling the secretion of lingual GLP-1. This regulatory loop, probably triggered by the LCFA-GPR120 interaction, might contribute to the high palatability of foods rich both in fat and sugar.

yearjournalcountryeditionlanguage
2012-08-21Journal of Lipid Research
10.1194/jlr.m025874http://www.sciencedirect.com/science/article/pii/S002222752041243X