0000000001145806

AUTHOR

Steven M. Sparks

showing 2 related works from this author

Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity

2012

Glucagon-like peptide-1 (GLP-1) signaling modulates sweet-taste sensitivity in the mouse. Because circumvallate papillae (CVPs) express both GLP-1 and its receptor, a local regulation has been suggested. However, whether dietary lipids are involved in this regulation, as shown in the gut, is unknown. By using a combination of biochemical, immunohistochemical, and behavioral approaches, the present data i) confirm the role of GLP-1 signaling in the attraction for sucrose, ii) demonstrate that minute quantities of long-chain FAs (LCFAs) reinforce the attraction for sucrose in a GLP-1 receptor-dependent manner, iii) suggest an involvement of the LCFA receptor GPR120 expressed in taste buds in …

CD36 Antigensmedicine.medical_specialtyTasteendocrine systemCD36Blotting WesternQD415-436eating behaviorReal-Time Polymerase Chain ReactionBiochemistryGlucagon-Like Peptide-1 ReceptorReceptors G-Protein-CoupledMiceEndocrinologyTAS1R3TAS1R2Glucagon-Like Peptide 1Cell Line TumorInternal medicinelong-chain fatty acidReceptors GlucagonmedicineAnimalsHumansSecretionObesityReceptorLingual papillaResearch Articlesbiologydigestive oral and skin physiologyGPR120healthCell BiologyTaste BudsImmunohistochemistryMice Inbred C57BLEndocrinologyobesity riskbiology.proteinJournal of Lipid Research
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Impact of long chain fatty acids on sweet taste sensitivity in mice. Role of the GPR120/GLP-1 signaling

2011

Nutrition and DieteticsBiochemistryGPR120Sweet tasteSensitivity (control systems)BiologyLong chainGeneral PsychologyAppetite
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