6533b861fe1ef96bd12c5726

RESEARCH PRODUCT

Divinyl Sulfone Cross-Linked Hyperpolymeric Human Haemoglobin as an Artificial Oxygen Carrier in Anaesthetized Spontaneously Breathing Rats

Wolfgang BarnikolStefan GuthHarald Pötzschke

subject

Oncotic pressureKidneyHeart Injurymedicine.medical_specialtychemistry.chemical_elementOxygen deficitDivinyl sulfoneOxygenmedicine.anatomical_structureEndocrinologyBlood lossBiochemistrychemistryInternal medicinemedicineBreathing

description

Hyperpolymeric haemoglobin in concentrations necessary to transport oxygen in organism to a significant extent exhibits a negligible oncotic pressure as compared to that of plasma. This property makes hyperpolymeric haemoglobins suitable for development of an artificial oxygen transporting blood additive. With such an additive - in contrast to an oxygen transporting plasma expander - combating a chronic oxygen deficit of tissue (brain, heart, kidney, extremities or in case of anaemia) is possible. Using in these cases an isoncotic oxygen carrying plasma expander instead of an additive would be even more detrimental because of fluid load to heart, at least in case of heart injury. Chronic oxygen deficit is more frequent than acute one, e.g. sudden blood loss. But also a blood loss may be compensated with the aid of an artificial oxygen carrying blood additive in simultaneously applying a plasma expander. Advantage of this procedure is, that the doctor has the possibility to adjust the application of additive and expander to the individual case.

yearjournalcountryeditionlanguage
1994-01-01
https://doi.org/10.1007/978-1-4615-2468-7_27