The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle

6533b861fe1ef96bd12c58a0

RESEARCH PRODUCT

The Study of Carbamoyl Phosphate Synthetase 1 Deficiency Sheds Light on the Mechanism for Switching On/Off the Urea Cycle

Vicente Rubio Johannes Häberle Javier Cervera José M. Gallego Carmen Diez-fernandez

subject

Conformational change Carbamoyl-Phosphate Synthase I Deficiency Disease Allosteric regulation Carbamoyl-Phosphate Synthase (Ammonia)Urea cycle diseases 610 Medicine & health Biology Molecular Dynamics Simulation urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Glutamates 1311 Genetics Ammonia Enzyme Stability Genetics medicine 1312 Molecular Biology Humans Urea Hyperammonemia Site-directed mutagenesis Molecular Biology 030304 developmental biology chemistry.chemical_classification 0303 health sciences Site-directed mutagenesis urogenital system Mutagenesis Carbamoyl phosphate synthetase 1 Hyperammonemia Carbamoyl phosphate synthetase medicine.disease Allosteric regulation 3. Good health Protein Structure Tertiary Restrained molecular dynamics Kinetics Enzyme Biochemistry chemistry 10036 Medical Clinic Enzyme Urea cycle Mutation Inborn errors 030217 neurology & neurosurgery Signal Transduction

description

12 páginas, 4 figuras, 2 tablas.

year	journal	country	edition	language
2015-05-20

10.1016/j.jgg.2015.03.009 http://hdl.handle.net/10261/171164

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