6533b862fe1ef96bd12c6207
RESEARCH PRODUCT
Innovative strategies to treat skin wounds with mangiferin: fabrication of transferosomes modified with glycols and mucin
Elvira Escribano FerrerAmparo NácherAmparo NácherMaria Letizia MancaOctavio Díez-salesOctavio Díez-salesMaria ManconiMaría Pleguezuelos-villaAnna Maria FaddaCarla CaddeoMohamad AllawMatteo AroffuAmparo Ruiz Saurísubject
BioadhesiveXanthonesBiomedical EngineeringMedicine (miscellaneous)Bioengineering02 engineering and technologyDevelopmentPharmacologymedicine.disease_cause030226 pharmacology & pharmacy03 medical and health scienceschemistry.chemical_compoundGlycols0302 clinical medicineDermisIn vivoGlycerolmedicineGeneral Materials ScienceMangiferinSkinGlicolsWound Healingintegumentary systemMucinMucins021001 nanoscience & nanotechnologySkin diseasesmedicine.anatomical_structurechemistryMalalties de la pell0210 nano-technologyWound healingOxidative stressdescription
Aim: The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions. Materials & methods: Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico–chemical features were assessed, along with the efficacy against oxidative stress and skin wounds in vitro and in vivo. Results: Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their proliferation. The wound healing and anti-inflammatory efficacy of glycoltransfersomes were confirmed in vivo. Conclusion: Results confirmed the potential of glycoltransfersomes in preventing/treating of skin lesions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |