6533b862fe1ef96bd12c6b46

RESEARCH PRODUCT

A lymphocyte-glia connection sets the pace for smoldering inflammation

Frauke ZippStefan Bittner

subject

Chronic ActiveLymphocyteMultiple sclerosisCentral nervous systemInflammationBiologymedicine.diseaseChronic inflammatory disorderGeneral Biochemistry Genetics and Molecular Biologymedicine.anatomical_structuremedicineIn patientDisability progressionmedicine.symptomNeuroscience

description

Successful therapeutic options directly targeting disability progression in patients with multiple sclerosis (MS), a chronic inflammatory disorder of the central nervous system, are lacking. Now, a study published in Nature by Absinta and colleagues profiles a lymphocyte-glia connection at the edge of chronic active lesions that continuously drives neurodegenerative pathways.

yearjournalcountryeditionlanguage
2021-11-01Cell
https://doi.org/10.1016/j.cell.2021.10.018