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RESEARCH PRODUCT

Oral squamous cell carcinoma mimicking osteonecrosis of the jaw: a case report

Erasmo RubinoGiuseppina CampisiVera PanzarellaOlga Di FedeP TozzoMartina Iurato CarboneGiacomo OteriRodolfo Mauceri

subject

medicine.medical_specialtymedicine.diagnostic_testHypesthesiabusiness.industrymedicine.medical_treatmentBisphosphonateInferior alveolar nervemedicine.diseaseDermatologystomatognathic diseasesPathognomonicBiopsymedicineMedical historyOsteonecrosis of the jawbusinessOral medicine

description

Osteonecrosis of the jaw (ONJ) is a well-known adverse drug reaction to bisphosphonate (BP) treatment. ONJ diagnosis is usually based on the patient’s medical/medication histories and on the clinical/radiological features of necrotic bone (frequently exposed). Furthermore, in case of mandibular involvement, patients may present pain and/or hypesthesia of the inferior alveolar nerve. There are no pathognomonic clinical and radiological signs of ONJ, and in doubtful cases, the histologic examination is recommended. We report a case of a woman attending to our sector of Oral Medicine (AOUP “P. Giaccone” Palermo, Italy) with a mandibular bone exposure after implants loss and a medical history of BPs. Biopsy specimens demonstrated proliferation of oral squamous cell carcinoma (OSCC). Even if the role of biopsy in diagnosis ONJ is still a controversial issue, it is mandatory in case of OSCC suspicious.  

yearjournalcountryeditionlanguage
2021-04-12
https://doi.org/10.32388/ic2qds