ChemInform Abstract: Synthesis and Pharmacological Activities of Novel 3-(Isoxazol-3-yl)-quinazolin-4(3H)-one Derivatives.

6533b862fe1ef96bd12c75ef

RESEARCH PRODUCT

ChemInform Abstract: Synthesis and Pharmacological Activities of Novel 3-(Isoxazol-3-yl)-quinazolin-4(3H)-one Derivatives.

Benedetta Maggio Nunzio Guido Mangano Fabiana Plescia Demetrio Raffa Giuseppe Daidone Vincenza Maria Catena Cutuli Antonina Caruso

subject

Acetic acid chemistry.chemical_compound Chemistry Analgesic medicine Phenylbutazone Peritonitis General Medicine Pharmacology medicine.disease Acute toxicity medicine.drug

description

Several new 3-(isoxazol-3-yl)-quinazolin-4(3H)-one derivatives were synthesized and tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effect. A few compounds were as active as phenylbutazone in the writhing and acetic acid peritonitis tests. They had a very low ulcerogenic effect.

year	journal	country	edition	language
2010-06-15	ChemInform

https://doi.org/10.1002/chin.199925228

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