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RESEARCH PRODUCT

Therapeutic vaccines for cancer: an overview of clinical trials

Håkan MellstedtGustav GaudernackWinald R. GerritsenChristoph HuberJohn WagstaffNick ThatcherSuzy SchollChristoph C. ZielinskiIan FaulknerIgnacio MeleroGiorgio Parmiani

subject

MaleLung Neoplasmsmedicine.medical_treatmentBreast NeoplasmsActive immunotherapyCancer VaccinesImmune systemAdjuvants ImmunologicCancer immunotherapyAntigens NeoplasmNeoplasmsmedicineHumansCarcinoma Renal CellMelanomaClinical Trials as Topicbusiness.industryImmunotherapy ActiveProstatic NeoplasmsCancerImmunotherapymedicine.diseaseKidney NeoplasmsPancreatic NeoplasmsClinical trialOncologyDrug developmentImmunizationHematologic NeoplasmsUrological cancers Radboud Institute for Health Sciences [Radboudumc 15]ImmunologyFemaleColorectal Neoplasmsbusiness

description

The therapeutic potential of host-specific and tumour-specific immune responses is well recognized and, after many years, active immunotherapies directed at inducing or augmenting these responses are entering clinical practice. Antitumour immunization is a complex, multi-component task, and the optimal combinations of antigens, adjuvants, delivery vehicles and routes of administration are not yet identified. Active immunotherapy must also address the immunosuppressive and tolerogenic mechanisms deployed by tumours. This Review provides an overview of new results from clinical studies of therapeutic cancer vaccines directed against tumour-associated antigens and discusses their implications for the use of active immunotherapy. © 2014 Macmillan Publishers Limited.

yearjournalcountryeditionlanguage
2014-01-01
10.1038/nrclinonc.2014.111https://cronfa.swan.ac.uk/Record/cronfa57728