6533b863fe1ef96bd12c77ce
RESEARCH PRODUCT
Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study
O MarroneS BattagliaP SteiropoulosO BasogluJ KvammeS RyanJ PepinJ VerbraeckenL GroteJ HednerM BonsignoreU AnttalainenT SaaresrantaF BarbéS TasbakanP BielickiM KumorR DumitrascuR SchulzP EscourrouG RoismanI FietzeT PenzelB KentW McnicholasP LévyJ PépinR TamisierL LavieP LavieJ MasaJ MontserratA PatakaR PlywaczewskiP SliwinskiM PretlR RihaD RodensteinR TkacovaG VaroneckasH VrintsA. VitolsCarolina LombardiGianfranco Paratisubject
MaleComorbidityBody Mass IndexCohort StudiesBehavioral Neuroscience0302 clinical medicineRisk FactorsPrevalenceobstructive sleep apneaAged 80 and overSex CharacteristicsSleep Apnea ObstructiveMedicine (all)Sleep apneaGeneral MedicineMiddle AgedEuropeHypertensionCardiologynephropathyepidemiologyFemaleGlomerular Filtration RateCohort studyAdultmedicine.medical_specialtyAdolescentPolysomnographyCognitive NeuroscienceRenal functionSettore MED/10 - Malattie Dell'Apparato Respiratoriota3111NephropathyYoung Adult03 medical and health sciencesInternal medicinemedicineHumansObesityRenal Insufficiency ChronicAgedHeart Failurehypoxiabusiness.industrymedicine.diseaseOxygenObstructive sleep apneaCross-Sectional Studies030228 respiratory systemHeart failurePhysical therapyHuman medicinebusinessBody mass index030217 neurology & neurosurgeryKidney diseasedescription
Abstract: The cross-sectional relationship of obstructive sleep apnea with moderate to severe chronic kidney disease, defined as an estimated glomerular filtration rate = 30) was found in 34% of subjects. The lowest nocturnal oxygen saturation was 81 +/- 10.2%. Chronic kidney disease prevalence in the whole sample was 8.7% or 6.1%, according to the Modification of Diet in Renal Disease or the Chronic Kidney Disease-Epidemiology Collaboration equations, respectively. Subjects with lower estimated glomerular filtration rate were older, more obese, more often female, had worse obstructive sleep apnea and more co-morbidities (P < 0.001, each). With both equations, independent predictors of estimated glomerular filtration rate < 60 were: chronic heart failure; female gender; systemic hypertension; older age; higher body mass index; and worse lowest nocturnal oxygen saturation. It was concluded that in obstructive sleep apnea, chronic kidney disease is largely predicted by co-morbidities and anthropometric characteristics. In addition, severe nocturnal hypoxaemia, even for only a small part of the night, may play an important role as a risk factor for kidney dysfunction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | Journal of Sleep Research |