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RESEARCH PRODUCT

Role of leuprolide acetate depot in hysteroscopic surgery: a controlled study.

N ChianchianoEttore CittadiniMassimo PetronioAntonio Perino

subject

Adultmedicine.medical_specialtyDepotHysteroscopyHysteroscopic surgeryEndometriumObstetrics and gynaecologymedicineOperating timeHumansProspective StudiesProspective cohort studyPreoperative treatmentGynecologymedicine.diagnostic_testbusiness.industryUterusUterine bleedingObstetrics and GynecologyGeneral MedicineEndoscopySurgeryClinical trialReproductive MedicineHysteroscopyDelayed-Action PreparationsUterine NeoplasmsMyometriumFemaleUterine HemorrhageLeuprolidebusinessAfter treatment

description

Objective To evaluate leuprolide acetate (LA) depot (Enantone Depot, Takeda, Italy) when administered preoperatively in hysteroscopic surgery. Design Prospective, comparative study. Setting University Clinic of Obstetrics and Gynecology. Patients One hundred ninety-three patients (114 pretreated with LA depot and 79 controls) who underwent hysteroscopic surgery for uterine septa (group A), submucous fibroids (group B), and abnormal uterine bleeding (group C). Results In groups B and C there was a significant reduction in the operating time, bleeding during the operation, and the amount of distention medium required after LA depot administration, but no significant differences in surgical feasibility or efficacy were found in group A patients after treatment. Conclusion Preoperative treatment with LA depot is effective in making hysteroscopic surgery easier.

yearjournalcountryeditionlanguage
1993-03-01Fertility and sterility
10.1016/s0015-0282(16)55790-2https://pubmed.ncbi.nlm.nih.gov/8458448