6533b86cfe1ef96bd12c8055
RESEARCH PRODUCT
A specific anti-aggressive effect of repeatedly administered lobeline.
M. Carmen OterinoM. Carmen CarrascoRosa RedolatPaul F. Brainsubject
MaleNicotineMedicine (miscellaneous)Male micePharmacologyMotor ActivityDrug Administration ScheduleNicotinechemistry.chemical_compoundMiceRepeated treatmentAgonistic behaviourmedicineAnimalsLobelineMotor activityNicotinic AgonistsPharmacologyDose-Response Relationship DrugAggressionAggressionPsychiatry and Mental healthNicotinic agonistchemistrySocial IsolationLobelinemedicine.symptomPsychologyAgonistic Behaviormedicine.drugdescription
The effects of chronic treatments with nicotinic agonists on agonistic encounters have received little attention. The effects of repeated (for 10 days) SC administration of (-)-lobeline (9.3, 18.6 and 37.2 micromol/kg) and (-)-nicotine (0.93, 1.86 and 3.72 micromol/kg) were evaluated using the mouse isolation-induced aggression model. Individually housed OF1 male mice served as experimental animals and were confronted by 'standard opponents'. Each mouse was tested only once on the last day of the repeated drug treatment. Videotaped agonistic encounters were analysed estimating the times allocated to 11 behavioural categories. Repeated treatment with the highest dose of lobeline diminished attack behaviour without significantly increasing immobility or changing any other behavioural category involving motor activity. In contrast, nicotine did not significantly alter time allocated to any behavioural category.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-07-20 | Addiction biology |