6533b86cfe1ef96bd12c8205
RESEARCH PRODUCT
An efficient one pot transfer hydrogenation and N-alkylation of quinolines with alcohols mediated by Pd/C/Zn
Belén AbarcaRafael BallesterosRosa Adamsubject
AlkylationMolecular StructureHydrogenOrganic Chemistrychemistry.chemical_elementOne-StepAlkylationTransfer hydrogenationBiochemistryCarbonZincchemistryAlcoholsQuinolinesOrganic chemistryHydrogenationPhysical and Theoretical ChemistryPalladiumdescription
A Pd/C/Zn mixture with alcohols has been revealed to be an efficient transfer hydrogenation system to quinolines. Furthermore, the metals mixture is able to activate alcohols as N-alkylating agents in a hydrogen autotransfer process. 1,2,3,4-Tetrahydroquinolines and N-alkylated tetrahydroquinolines from quinolines have been obtained with excellent yields in one step.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-19 | Organic & Biomolecular Chemistry |