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RESEARCH PRODUCT

Inflammatory and immunological profile in COPD secondary to organic dust exposure.

Thibaud SoumagneSophia KeddacheOlivier AdoteviJean-charles DalphinLucie LaurentCaroline LaheurteLaura Boullerot

subject

MaleT-LymphocytesImmunologyStimulationInflammationPeripheral blood mononuclear cellPulmonary Disease Chronic ObstructiveImmune systemOccupational ExposuremedicineTobacco SmokingImmunology and AllergyHumansOrganic ChemicalsAgedInflammationCOPDB-Lymphocytesbiologybusiness.industryCD28AgricultureDustMiddle Agedmedicine.diseaserespiratory tract diseasesKiller Cells NaturalCase-Control StudiesImmunologybiology.proteinLeukocytes MononuclearCytokinesFemalemedicine.symptombusinessCD8Flagellin

description

Inflammatory response in patients with COPD secondary to organic dust exposure (OD-COPD) is poorly understood. We therefore aimed to characterize inflammatory and immune profile from peripheral blood mononuclear cells (PBMC) in a group of patients with mild-to-moderate COPD secondary to organic dust exposure (OD-COPD), tobacco smoking (T-COPD), or both. We compared T, B and NK cells distribution and inflammatory (TNF-α, Il-1β, IL-6), type 1 (IFN-γ), type 2 (IL-4, IL-13) and type 3 (IL-17) immunity related cytokines at baseline, and after stimulation with LPS, flagellin and CD3/CD28 beads in all COPD groups. OD-COPD displayed significantly lower NK cells and CD8+ T cells compared with controls. After flagellin stimulation, T-COPD had significantly lower IL-13 levels than OD-COPD and controls (p  0.05) whereas IFN-γ tended to be lower in OD-COPD. All COPD groups displayed higher IL-1β and IL-17 than controls after CD3/CD28 stimulation. Inflammatory responses in OD-COPD were different from T-COPD. OD-COPD displayed higher levels of type 2 immunity related cytokines.

yearjournalcountryeditionlanguage
2021-08-01Clinical immunology (Orlando, Fla.)
10.1016/j.clim.2021.108798https://pubmed.ncbi.nlm.nih.gov/34280578