0000000000434882
AUTHOR
Laura Boullerot
showing 4 related works from this author
Metronomic cyclophosphamide induces regulatory T cells depletion and PSA‐specific T cells reactivation in patients with biochemical recurrent prostat…
2019
Biochemical recurrence (BCR) occurs in up to 40% of prostate cancer patients after prostatectomy. In our study, we performed an immune monitoring study in 20 prostate cancer patients with BCR previously treated with metronomic cyclophosphamide (mCTX). We observed a decrease of regulatory T cells (Tregs) from 2 months and this was more pronounced after 6 months of mCTX treatment. This drop of Tregs was associated with increased level of activated HLADR+ CD45R0+ T cells in peripheral blood. Furthermore, a reactivation of Th1 polarized anti-PSA T-cell response was detected in BCR patients treated with mCTX. However, dendritic cell subsets counts and activation were not influenced by the treatm…
Naturally Occurring Telomerase-Specific CD4 T-Cell Immunity in Melanoma.
2020
CD4 T cells play a key role in anticancer immunity. In this study, we investigate the clinical relevance of circulating CD4 T helper type 1 (Th1) response against telomerase (anti-TERT Th1 response) in patients with melanoma. The spontaneous anti-TERT Th1 response was detected in 54.5% (85/156) of patients with melanoma before treatment. The prevalence of this systemic response was inversely related to Breslow thickness >1 mm and American Joint Committee on Cancer stage ≥II (P = 0.001 and 0.032, respectively). In contrast to patients treated with targeted therapies, the anti-TERT Th1 immunity was associated with an objective response after immune checkpoint inhibitors treatment. Hence, 86% …
Immunité spécifique anti-télomérase dans le mélanome
2020
La reponse immunitaire lymphocytaire T CD4 Th1 joue un role important dans l’immunite anti tumorale et a ete etudiee dans de nombreux cancers. Nous avons evalue la reponse immunitaire T CD4 Th1 grâce a la reponse T CD4 Th1 anti-telomerase (anti-TERT) chez des patients atteints de melanome de tous stades AJCC. La reponse anti-TERT des lymphocytes de patients atteints de melanome etait evaluee par ELISpot IFN-γ et comparee aux donnees clinico-biologiques des patients. Au total, 171 patients atteints de melanome etaient inclus et 156 d’entre eux avaient une evaluation de la reponse anti-TERT disponible. Une reponse anti-TERT etait retrouvee chez 55 % des patients. La reponse anti-TERT etait mo…
Inflammatory and immunological profile in COPD secondary to organic dust exposure.
2021
Inflammatory response in patients with COPD secondary to organic dust exposure (OD-COPD) is poorly understood. We therefore aimed to characterize inflammatory and immune profile from peripheral blood mononuclear cells (PBMC) in a group of patients with mild-to-moderate COPD secondary to organic dust exposure (OD-COPD), tobacco smoking (T-COPD), or both. We compared T, B and NK cells distribution and inflammatory (TNF-α, Il-1β, IL-6), type 1 (IFN-γ), type 2 (IL-4, IL-13) and type 3 (IL-17) immunity related cytokines at baseline, and after stimulation with LPS, flagellin and CD3/CD28 beads in all COPD groups. OD-COPD displayed significantly lower NK cells and CD8+ T cells compared with contro…