6533b86cfe1ef96bd12c82b3
RESEARCH PRODUCT
The effect of antenatal intravenous immunoglobulin on ascending intrauterine infection after preterm premature rupture of the membranes: a pilot study
R LissnerM HöckelTh. BeckR ZielbergA Queisser-luftH Stopfkuchensubject
AdultFetal Membranes Premature Rupturemedicine.medical_specialtyPromChorioamnionitisInfant Newborn Diseaseslaw.inventionRandomized controlled trialPregnancylawHumansMedicineProspective StudiesPregnancy Complications InfectiousProspective cohort studyUterine DiseasesPregnancybusiness.industryObstetricsInfant NewbornImmunoglobulins IntravenousObstetrics and GynecologyBacterial Infectionsmedicine.diseaseClinical trialPediatrics Perinatology and Child HealthCohortFemalebusinessComplicationdescription
Ascending infection is a serious threat in pregnancies complicated by preterm premature rupture of the membranes (PROM). In a controlled randomized prospective pilot study (n = 18) we have evaluated the effect of intravenous IgM enriched immunoglobulin given to the mothers 24-48 hours after preterm PROM in reducing ascending infection. Using a validated infection score from laboratory and clinical data at birth, we found a significant reduction of probable infection in the neonates of the treatment group compared to the control group (p = 0.0022). Histopathological investigation of the placentas, membranes and umbilical cords revealed significantly lower stages and grades of chorioamnionitis in the treatment group (p = 0.036). From these preliminary results we conclude, that intravenous broad spectrum immunoglobulin given antenatally to patients with preterm PROM may reduce ascending infection. However, studies with a much larger cohort of patients are necessary to confirm these preliminary results and to detect potential clinical benefits from this treatment mode.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-01-01 | jpme |