6533b86cfe1ef96bd12c832e

RESEARCH PRODUCT

Behavioural studies on rats injected with l-cycloserine and other compounds

V. BonavitaM. LettieriP. Monaco

subject

PharmacologyAminobutyratesResearchCycloserineAntagonistBrainPyridoxineMetabolismPharmacologyPyridoxineAminobutyric acidRatschemistry.chemical_compoundMetabolismHydroxylamineBiochemistrychemistryCycloserineConditioning PsychologicalAvoidance LearningIsoniazidmedicineAvoidance reactionPyridoxine Hydrochloridemedicine.drug

description

l-cycloserine, a cyclic derivative of O-substituted hydroxylamine, causes the suppression of the conditioned avoidance reaction in the rat. The subsequent injection of equimolar amounts of pyridoxine hydrochloride is responsible for a complete reversal of this suppression. The suppression of the conditioned response is not observed with the d-isomer of cycloserine. Isoniazid is a strong antagonist of l-cycoserine. Changes in the brain level of GABA under several conditions are described. These changes suggest though do not establish a relationship between the block of the conditioned response and the elevation of the aminoacid above its physiological concentration.

yearjournalcountryeditionlanguage
1964-02-12Psychopharmacologia
https://doi.org/10.1007/bf00413246