6533b86cfe1ef96bd12c8b01
RESEARCH PRODUCT
Green and Integrated Wearable Electrochemical Sensor for Chloride Detection in Sweat
Francesco LoprestiBernardo PatellaVito DivitaClaudio ZancaLuigi BottaNorbert RadacsiAlan O’riordanGiuseppe AielloMaïwenn Kersaudy-kerhoasRosalinda InguantaVincenzo La Carrubbasubject
SilverPolyestersSettore ING-IND/34 - Bioingegneria IndustrialeBiosensing TechniquesElectrochemical TechniquesBiochemistryAtomic and Molecular Physics and OpticsAnalytical ChemistryWearable Electronic DevicesSettore ING-IND/23 - Chimica Fisica ApplicataSettore ING-IND/22 - Scienza E Tecnologia Dei MaterialiChloridesSettore ING-IND/17 - Impianti Industriali MeccaniciHumansElectrical and Electronic Engineeringelectrochemical sensors; wearable sensor; chloride detection; electrolyte assisted electrospinning; environmental-friendly; laser cuttingSweatchloride detection electrochemical sensors electrolyte assisted electrospinning environmental-friendly laser cutting wearable sensor Humans Sweat Chlorides Silver Polyesters Electrochemical Techniques Wearable Electronic Devices Biosensing TechniquesInstrumentationdescription
Wearable sensors for sweat biomarkers can provide facile analyte capability and monitoring for several diseases. In this work, a green wearable sensor for sweat absorption and chloride sensing is presented. In order to produce a sustainable device, polylactic acid (PLA) was used for both the substrate and the sweat absorption pad fabrication. The sensor material for chloride detection consisted of silver-based reference, working, and counter electrodes obtained from upcycled compact discs. The PLA substrates were prepared by thermal bonding of PLA sheets obtained via a flat die extruder, prototyped in single functional layers via CO2 laser cutting, and bonded via hot-press. The effect of cold plasma treatment on the transparency and bonding strength of PLA sheets was investigated. The PLA membrane, to act as a sweat absorption pad, was directly deposited onto the membrane holder layer by means of an electrolyte-assisted electrospinning technique. The membrane adhesion capacity was investigated by indentation tests in both dry and wet modes. The integrated device made of PLA and silver-based electrodes was used to quantify chloride ions. The calibration tests revealed that the proposed sensor platform could quantify chloride ions in a sensitive and reproducible way. The chloride ions were also quantified in a real sweat sample collected from a healthy volunteer. Therefore, we demonstrated the feasibility of a green and integrated sweat sensor that can be applied directly on human skin to quantify chloride ions.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-10-27 |