6533b86dfe1ef96bd12c94f3

RESEARCH PRODUCT

Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana

C. YordanBénédicte PurnelleKelsi ScottS. Bray-allenT. StonekingJoseph A. MurrayB. MccullaghA. DüsterhöftK. GranderathP. VosW. R. MccombieRita AertM. FeldpauschMatt CordesM. ShekherJoelle KalickiKymberlie H. PepinR. Klein LankhorstBarbara HarrisA. MontfortM. CottonJ. ZhongJ. ZhongA. PettettDmitrij FrishmanA. BrandtS. AndrewsE. HolzerT. GibbonsMichael W. BevanS. DoseM. ZidanicM. LodhiElena CasacubertaD. BorkovaThomas PohlK. MclayM. KreisS. A. LanghamJ. CloudAnagnostis ArgiriouL. GnojB. GrymonprezEllson Y. ChenEllson Y. ChenK. HabermannMichael A. QuailDavid W. JohnsonM. De HaanS. GranatS. JohnsonS Müller-auerI'k. SwabyLucinda FultonC. BielkeJoerg HoheiselH. WedlerC. BergerM. Van StaverenC. GabelM. RoseP. KötterU. RamspergerG. BotheK.-d. EntianN. MillerH. HilbertWilhelm AnsorgeGuido VolckaertG. ClabauldP. RidleyA. CroninJohn SpiethA. HasegawaK. SchutzJoanne O. NelsonDavid BentleyS. StockerR. ShahA. JohnsonA. JohnsonJ. DoggettE. RyanR. WambuttA. HerzlD. DaunerR. HillerM. WeichselgartnerM. De La BastideH. SunRichard K. WilsonPatrick MinxR. MayesM. Van MontaguL. ParnellR. PrestonJohar AliCorinne E. JoshuS. AubourgMarco A. MarraCindy StrongM. SchäferA. BerghoffM. D. BarguesRosario LiguoriKlaus F. X. MayerLori SpiegelJ. GielenL. BilhamP. ZaccariaH. Van Den DaeleV De SimoneA.c. MaarseIan BancroftDan LaymanJ. HaufA. TorresR. De ClercqR. MachePetra BrandtR. FelberMichael A. RiegerK. KempM. LyneD. TaconS. TillNicola LennardLeslie A. GrivellJ. Van Der SchuerenS. SchnablD. VitaleHans-werner MewesS. HallNancy TerrynA Perez-perezF. VandenbusscheKai LemckeS. HempelJ. HoffmanP. MaP. MaE. PiravandiP. LatreilleHui DuWolfgang ZimmermannP. FrancsM. GrimmSindy NeumannA. AbbottPere PuigdomènechM. KayM. BraekenA. MündleinG. HarmonLeo HeijnenW. SchmidtMarc BoutryNadim ShohdyJ. Abu-threidehPatrik SchollerF. QuigleyMarie-adèle RajandreamT. GrecoLadeana W. HillierE. DefoorSteffen HeberAbdul HameedM. BraunS. RechmannJohan RobbenL. ClarkMartin D. WatsonB. ObermaierA. MateroTina GravesF. ChefdorB. AntonoiuA. O'shaughnessyWim G. DirkseI. WeltjensD. PortatelleJason B. KramerT. H. LöhnertM. RodriguezD. VilRobert A. MartienssenD. HaaseO. MassenetR. VillarroelI. BastiaensP. MooijmanN. WeberMicheline VandenbolM. ScharfeC. SchüllerGeorge MurphyH. BlöckerJane RogersBob FultonB. LamarLaura CourtneyWillem J. StiekemaMike DanteS. BerneiserVladimir BenesE. HuangT. JesseNeilay DedhiaE. BentBerthold FartmannT. SchmidtheiniM. FuchsC. GeiselMario MüllerK. JonesA. De KeyserManuel Pérez-alonsoElaine R. MardisMarleen VoetS. SchwarzA. LecharnyMichel DelsenyS. LamberthK. DroneP. SheetT. WeitzeneggerM. SehkonB. ReichertY. J. ChuangC. BuysshaertJavier TerolSander PetersR. CookeJennifer Edwards

subject

GeneticsMultidisciplinaryChromosome 4Sequence analysisArabidopsisGene densityBiologybiology.organism_classificationGenomeGeneHomology (biology)Caenorhabditis elegans

description

The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996. Here we report one of the first milestones of this project, the sequence of chromosome 4. Analysis of 17.38 megabases of unique sequence, representing about 17% of the genome, reveals 3,744 protein coding genes, 81 transfer RNAs and numerous repeat elements. Heterochromatic regions surrounding the putative centromere, which has not yet been completely sequenced, are characterized by an increased frequency of a variety of repeats, new repeats, reduced recombination, lowered gene density and lowered gene expression. Roughly 60% of the predicted protein-coding genes have been functionally characterized on the basis of their homology to known genes. Many genes encode predicted proteins that are homologous to human and Caenorhabditis elegans proteins.

yearjournalcountryeditionlanguage
1999-12-16Nature
10.1038/47134https://doi.org/10.1038/47134