Dysphonia in Children – Part 2

Hintergrund: National und international gibt es unterschiedliche Vorstellungen und Konzepte zur Diagnostik und Therapie von Dysphonien bei Kindern. Die in verschiedenen Publikationen vertretenen Auffassungen hinsichtlich der Behandlung reichen vom Abwarten einer Selbstheilung („wait and see“) uber Phonochirurgie (z. B. von Stimmlippenknotchen) bis hin zu Stimmubungstherapie und Psychotherapie. Ziel: Ziel der vorliegenden Arbeit war es deshalb, einen interdisziplinaren Konsens uber die diagnostischen und therapeutischen Moglichkeiten bei kindlichen Dysphonien herbeizufuhren. Methodik: Nominaler Gruppenprozess, interdisziplinare Diskussion uber diagnostische Moglichkeiten und Behandlungskonze…

New results on the Roper resonance and the P_{11} partial wave

Properties of the Roper resonance, the first scalar excitation of the nucleon, are determined. Pole positions and residues of the $P_{11}$ partial wave are studied in a combined analysis of pion- and photo-induced reactions. We find the Roper pole at $\{(1371\pm7)-i(92\pm10)\}$ MeV and an elasticity of $0.61\pm 0.03$. The largest decay coupling is found for the $N\sigma$ ($\sigma=(\pi\pi)$-$S$-wave). The analysis is based on new data on $\gamma p\to p\pi^0\pi^0$ for photons in the energy range from the two-pion threshold to 820 MeV from TAPS at Mainz and from 0.4 to 1.3 GeV from Crystal Barrel at Bonn and includes further data from other experiments. The partial wave analysis excludes the p…

Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.

Arabidopsis thaliana is an important model system for plant biologists. In 1996 an international collaboration (the Arabidopsis Genome Initiative) was formed to sequence the whole genome of Arabidopsis and in 1999 the sequence of the first two chromosomes was reported. The sequence of the last three chromosomes and an analysis of the whole genome are reported in this issue. Here we present the sequence of chromosome 3, organized into four sequence segments (contigs). The two largest (13.5 and 9.2 Mb) correspond to the top (long) and the bottom (short) arms of chromosome 3, and the two small contigs are located in the genetically defined centromere. This chromosome encodes 5,220 of the rough…

Dysphonien bei Kindern – Teil 1

Hintergrund: Uber die Behandlung von Dysphonien im Kindesalter gibt es international aktuell keinen Konsens und keine Leitlinie. Zudem differieren die in verschiedenen Publikationen vertretenen Auffassungen uber Ursachen, Entwicklung und Pravalenzen stark. Ziel: Ziel der vorliegenden Arbeit war es deshalb, einen interdisziplinaren Konsens bezuglich der Pathogenese, Atiologie und Auswirkungen von Stimmstorungen bei Kindern herbeizufuhren. Methodik: Nominaler Gruppenprozess, interdisziplinarer Erfahrungsaustausch, Literaturrecherche und Evidenzlevelbewertung von Publikationen zu Ursachen, Haufigkeiten, Entstehung und Entwicklung von Dysphonien bei Kindern und Jugendlichen. Ergebnisse: Die aus…

Mass and Γ3π0/Γγγ decay branching ratio of theη-meson from the p(γ, η)p reaction

Near threshold photoproduction ofη-mesons from the proton has been measured at the MAMI accelerator with the TAPS spectrometer. The mass of theη-meson was deduced from the threshold energy forη-photoproduction. The result of m η =(547.12 ± 0.06 ± 0.25) MeV supports the low value of theη-mass reported from a dp →3Heη measurement at SATURNE in 1992. Theη-decay branching ratio Γ3π0/Γγγ was measured to be (0.832±0.005±0.012).

Progress in Arabidopsis genome sequencing and functional genomics

Arabidopsis thaliana has a relatively small genome of approximately 130 Mb containing about 10% repetitive DNA. Genome sequencing studies reveal a gene-rich genome, predicted to contain approximately 25 000 genes spaced on average every 4.5 kb. Between 10 to 20% of the predicted genes occur as clusters of related genes, indicating that local sequence duplication and subsequent divergence generates a significant proportion of gene families. In addition to gene families, repetitive sequences comprise individual and small clusters of two to three retroelements and other classes of smaller repeats. The clustering of highly repetitive elements is a striking feature of the A. thaliana genome emer…

Advances in Technology for High-Energy Subnuclear Physics. Contribution of the LAA Project.

Transparency ratio in γA→η′A′ and the in-medium η′ width

Abstract The photoproduction of η ′ -mesons off different nuclei has been measured with the CBELSA/TAPS detector system for incident photon energies between 1500–2200 MeV. The transparency ratio has been deduced and compared to theoretical calculations describing the propagation of η ′ -mesons in nuclei. The comparison indicates a width of the η ′ -meson of the order of Γ = 15 – 25 MeV at ρ = ρ 0 for an average momentum p η ′ = 1050 MeV / c , at which the η ′ -meson is produced in the nuclear rest frame. The inelastic η ′ N cross section is estimated to be 3–10 mb. Parameterizing the photoproduction cross section of η ′ -mesons by σ ( A ) = σ 0 A α , a value of α = 0.84 ± 0.03 has been dedu…

Klinische Pharmakologie I

Rifampicin (RMP) induziert nach mehrtagiger Gabe die mischfunktionellen Oxygenasen in der Leber, so das auch sein eigener Metabolismus beschleunigt wird (Eigeninduktion, Acocella 1978a). Wie wir beobachteten, nahmen die RMP-Plasmaspiegel unter oraler Dauertherapie starker ab als bei intravenoser Applikation (Musch et al. 1982; Loos et al. 1983). Klinisch zeigten 30 initial mit RMP intravenos behandelte Patienten mit offener Lungentuberkulose eine schnellere Sputumnegativierung und Rontgenbefundbesserung im Vergleich zu 48 oral therapierten Patienten (Kombinationstherapie: RMP-Isoniazid-Ethambutol). So war z. B. die Sputumkulturkonversion nach dem 1. Behandlungsmonat bei intravenoser RMP-Gab…

Observation of a unitary cusp in the thresholdγp→π0preaction

A rigorous multipole analysis of the recent $\ensuremath{\gamma}p\ensuremath{\rightarrow}{\ensuremath{\pi}}^{0}p$ cross-section measurement is presented. The data were taken using the photon spectrometer TAPS at the tagged photon beam of the Mainz microtron. The $s$ and $p$ wave multipoles were extracted using minimal model assumptions. The predicted unitary cusp for the $s$-wave multipole ${E}_{0+}$ due to the two step $\ensuremath{\gamma}p\ensuremath{\rightarrow}{\ensuremath{\pi}}^{+}n\ensuremath{\rightarrow}{\ensuremath{\pi}}^{0}p$ reaction was observed. The results are consistent with one-loop chiral perturbation theory calculations for which three low-energy constants have been determi…

Single and double πo-photoproduction from the deuteron

Photoproduction of neutral pions from the deuteron has been studied for incident photon energies from 200 MeV to 792 MeV with the TAPS detector at the Mainz MAMI accelerator. Total and differential cross sections covering the full angular range have been obtained for coherent and incoherent single πo-photoproduction. Good agreement between model predictions and the data was found for the coherent process. The incoherent cross section in the energy region of the Δ(1232)-resonance is overestimated by existing models. A comparison to model predictions indicates that final state interaction effects are much more important than for the coherent reaction. However, the angular dependence of the da…

Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana

The higher plant Arabidopsis thaliana (Arabidopsis) is an important model for identifying plant genes and determining their function. To assist biological investigations and to define chromosome structure, a coordinated effort to sequence the Arabidopsis genome was initiated in late 1996. Here we report one of the first milestones of this project, the sequence of chromosome 4. Analysis of 17.38 megabases of unique sequence, representing about 17% of the genome, reveals 3,744 protein coding genes, 81 transfer RNAs and numerous repeat elements. Heterochromatic regions surrounding the putative centromere, which has not yet been completely sequenced, are characterized by an increased frequency …