Myocardial Glutathione Alterations in Acute Coronary Occlusion in the Dog

6533b86dfe1ef96bd12c96be

RESEARCH PRODUCT

Myocardial Glutathione Alterations in Acute Coronary Occlusion in the Dog

Luis Such Jose Viña Antonio Alberola Francisco J. Romero Francisco Javier Palao Gil Guillermo-t. Sáez Alfredo Montoro

subject

inorganic chemicals medicine.medical_specialty Ischemic myocardium Ischemia Coronary Disease Biochemistry chemistry.chemical_compound Dogs fluids and secretions Reference Values Internal medicine medicine Animals Normal range Glutathione Disulfide Total glutathione business.industry Myocardium Glutathione medicine.disease Coronary Vessels Glutathione Kinetics chemistry Coronary occlusion Anesthesia Cardiology business

description

Glutathione (GSH) decreases in dog mycocardium upon acute coronary occlusion when compared with sham-operated dogs. Total glutathione content (GSHeq = GSH + ZGSSG) remains unchanged throughout the experiment (6 h after surgery) in both sham- and acute coronary occlusion-operated dogs. GSSG and GSH/GSSG ratio increases and decreases respectively in all animals but tends to reach the normal value after 6 h in sham-operated dogs. Both parameters (GSSG and GSH/GSSG ratio) remain altered in acute coronary occlusion-operated ones. This alteration of glutathione status in ischemic myocardium is discussed.

year	journal	country	edition	language
1987-01-01	Free Radical Research Communications

https://doi.org/10.3109/10715768709088085

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