Serotypes, Antibiotic Resistance, and Class 1 Integrons in Salmonella Isolates from Pediatric Cases of Enteritis in Tehran, Iran

6533b86dfe1ef96bd12c9733

RESEARCH PRODUCT

Serotypes, Antibiotic Resistance, and Class 1 Integrons in Salmonella Isolates from Pediatric Cases of Enteritis in Tehran, Iran

Caterina Mammina Reza Ranjbar Shohreh Farshad Giovanni M. Giammanco Parviz Owlia Aurora Aleo

subject

Salmonella typhimurium Serotype Settore MED/07 - Microbiologia E Microbiologia Clinica Salmonella Nalidixic acid Tetracycline Drug resistance Iran Settore MED/42 - Igiene Generale E Applicata Integron medicine.disease_cause Applied Microbiology and Biotechnology Microbiology Integrons Microbiology Antibiotic resistance Bacterial Proteins Disk Diffusion Antimicrobial Tests Salmonella Drug Resistance Bacterial medicine Humans Salmonella antibiotic resistance class 1 integrons Iran Amplified Fragment Length Polymorphism Analysis Serotyping Child biology Infant Hospitals Pediatric Enteritis Anti-Bacterial Agents Clone Cells Electrophoresis Gel Pulsed-Field Salmonella enteritidis Streptomycin Child Preschool Salmonella Infections biology.protein Animal Science and Zoology Food Science medicine.drug

description

The present study was conducted to investigate serotype distribution, antimicrobial resistance patterns, carriage of class 1 integron, and clonality of Salmonella strains isolated from patients aged 0-12 years in Tehran, Iran, during 2007-2008. A total of 139 Salmonella isolates were studied. Salmonella serotypes Enteritidis, Infantis, and Typhimurium included 84.9% of isolates, Enteritidis accounting for 41.7%. The most prevalent resistances were to doxycycline (64.7%), nalidixic acid (61.2%), tetracycline (51.8%), and streptomycin (42.8%). Fifty-three (38.1%) isolates contained class 1 integron. Eight different gene cassettes were identified, aadA1 being the most frequently encountered. Pulsed-field gel electrophoresis showed that integron-positive Salmonella strains belonging to serotypes Infantis, Enteritidis, and Typhimurium were attributed to two, three, and five different pulsotypes, respectively. The findings indicated that the distribution and drug resistance pattern of most prevalent Salmonella serotypes were broadly similar to that reported globally from human isolates. Presence of class 1 integrons was common among Salmonella serotypes in Tehran, Iran. Concurrent clonal expansion and horizontal transmission events seem to contribute to increase in drug resistance prevalence among Salmonella serotypes.

year	journal	country	edition	language
2011-04-01	Foodborne Pathogens and Disease

https://doi.org/10.1089/fpd.2010.0736