6533b86dfe1ef96bd12c9738
RESEARCH PRODUCT
Constituents of regenerated plants of Ophiorrhiza pumila; formation of a new glycocamptothecin and predominant formation of (3R)-deoxypumiloside over (3S)-congener
Mariko KitajimaJoachim StöckigtNorio AimiKazuki SaitoMio NakamuraHiromitsu Takayamasubject
CongenerOphiorrhiza pumilaChemistryStereochemistryCallusOrganic ChemistryDrug DiscoverymedicineEpimerBiochemistryCamptothecinmedicine.drugdescription
Abstract The regeneration of plantlets was successful from Ophiorrhiza pumila callus cultures, from which a new glucosyloxy camptothecin, 9-β-glucosyloxycamptothecin, together with 15 metabolites including six camptothecin-related alkaloids was isolated. (3S)-Deoxypumiloside, one of the plausible biogenetic precursors of camptothecin, could not be found, whereas the (3R) epimer was isolated from the regenerated plants.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-12-01 | Tetrahedron Letters |