6533b86dfe1ef96bd12c9f36

RESEARCH PRODUCT

The Role of Inflammation in Lymphoma

Antonino CarboneAnnunziata GloghiniArmando SantoroCarmelo Carlo-stellaClaudio Tripodo

subject

InflammationPathologymedicine.medical_specialtyTumor microenvironmentStromal cellLymphomatoid granulomatosisFollicular lymphomalymphomaInflammationBiologymedicine.diseaseBCL10Lymphomaimmune system diseaseshemic and lymphatic diseasesmedicinemedicine.symptomBrentuximab vedotinmedicine.drug

description

Human lymphomas usually develop in specialized tissue microenvironments characterized by different populations of accessory stromal and lymphoid cells that interact with malignant cells. A clinical role of the tumor microenvironment has recently emerged, bringing new knowledge and suggesting new ideas and targets for treatment. This chapter analyzes the microenvironment in human lymphomas highlighting the role of inflammation in their pathogenesis. Microenvironmental specificity is detailed according to different models including classic Hodgkin lymphoma (HL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), peripheral T-cell lymphoma, unspecified and angioimmunoblastic T-cell lymphoma (AITL).

yearjournalcountryeditionlanguage
2014-01-01
https://doi.org/10.1007/978-3-0348-0837-8_12