6533b86dfe1ef96bd12ca012

RESEARCH PRODUCT

Radical vaginal trachelectomy (RVT) combined with laparoscopic lymphadenectomy: Prospective study of 225 patients with early-stage cervical cancer

Mandy ManglerUlrike GrittnerVito ChianteraHermann HertelAnnabel SpekMalgorzata LanowskaK. HasenbeinDorothee SpeiserAchim SchneiderChristhardt Köhler

subject

Adultmedicine.medical_specialtyUterine Cervical NeoplasmUrologyUterine Cervical NeoplasmsRadical vaginal trachelectomyAdenocarcinomaYoung AdultGynecologic Surgical ProceduresGynecologic Surgical ProcedureVaginal TrachelectomyEarly-stage cervical cancer; Fertility-preserving surgery; Radical vaginal trachelectomyMedicineHumansProspective StudiesStage (cooking)Prospective cohort studyLaparoscopic lymphadenectomyCervical cancerLaparoscopic lymphadenectomyIntention-to-treat analysisbusiness.industryMedicine (all)Fertility-preserving surgeryObstetrics and GynecologyPerioperativeMiddle Agedmedicine.diseaseSettore MED/40 - Ginecologia E OstetriciaSurgeryProspective StudieOncologyEarly-stage cervical cancerCohortVaginaCarcinoma Squamous CellLymph Node ExcisionFemaleLaparoscopybusinessHuman

description

Objective: The aim of the study was to prove the surgical and oncological safety of radical vaginal trachelectomy (RVT) and laparoscopic lymphadenectomy for patients with early-stage cervical cancer who are seeking parenthood. Methods: A database of 225 patients with early-stage cervical cancer and intention to treat by RVT after laparoscopic lymphadenectomy was prospectively maintained. A total of 212 patients were treated according to the protocol. The procedure was preformed in a standardized manner, and life table analysis was applied. Results: In the cohort of patients treated according to protocol, 8 recurrences occurred and 4 patients died from recurrence. The median follow-up time was 37 months (range, 0-171 months). The 5-year recurrence-free and overall survival was 94.4% and 97.4%, respectively. Perioperative and short-term postoperative complications were rare (2.8% and 7.5%, respectively). No severe long-term complications occurred. Conclusions: Radical vaginal trachelectomy combined with laparoscopic lymphadenectomy is a safe method for treatment of patients with early-stage cervical cancer who are seeking parenthood.

yearjournalcountryeditionlanguage
2011-01-01
10.1097/igc.0b013e3182216aa7http://hdl.handle.net/11695/5502