6533b86dfe1ef96bd12ca098

RESEARCH PRODUCT

Anesthetics and Cerebral Protection in Patients Undergoing Carotid Endarterectomy

Nenad IlijevskiEsma R. IsenovicMiomir JovicMiomir JovicDragana Unic-stojanovicOlivera CekicRizzo ManfrediDjordje RadakSrdan Babic

subject

medicine.medical_specialtymedicine.medical_treatmentIschemiaCarotid endarterectomyAnesthesia GeneralNeuroprotectionSevofluraneBrain Ischemia03 medical and health sciences0302 clinical medicine030202 anesthesiologyInternal medicinemedicineAnimalsHumansIschemic PreconditioningSubclinical infectionEndarterectomy Carotidbusiness.industryGlutamate receptorPerioperativeHypoxia (medical)medicine.disease3. Good healthNeuroprotective AgentsAnesthesiology and Pain MedicineAnesthesiaAnesthetics InhalationCardiologymedicine.symptomCardiology and Cardiovascular Medicinebusiness030217 neurology & neurosurgerymedicine.drug

description

EREBRAL ISCHEMIA/HYPOXIA may occur in a vari-ety of perioperative circumstances. The main pathophy-siologic aspects involved in cerebral ischemia/reperfusion arecaused by adenosine triphosphate (ATP) consumption, theexcitotoxic actions of glutamate, changes in ionic homeostasis,and formation of free radicals (Fig 1). Outcomes from suchevents range from subclinical neurocognitive deficits to cata-strophic neurologic morbidity or death.

yearjournalcountryeditionlanguage
2015-02-01Journal of Cardiothoracic and Vascular Anesthesia
https://doi.org/10.1053/j.jvca.2014.05.019