6533b86dfe1ef96bd12cab87

RESEARCH PRODUCT

A New Phenanthrene Glycoside and Other Constituents from Dioscorea opposita

Anne Claire Mitaine-offerTomofumi MiyamotoHildebert WagnerMarie Aleth Lacaille-duboisMarc Sautour

subject

Antifungal AgentsMagnetic Resonance SpectroscopyDioscoreaceaeMicrobial Sensitivity TestsPalmitic acidchemistry.chemical_compoundDrug DiscoverymedicineGlycosidesCandida albicansCandidachemistry.chemical_classificationMolecular StructureTraditional medicinebiologyDioscoreaPlant ExtractsGlycosideGeneral ChemistryGeneral MedicinePhenanthrenesPhenanthrenebiology.organism_classificationAdenosineRhizomechemistryBiochemistryPhytochemicalDioscoreaRhizomemedicine.drug

description

Phytochemical investigation of the rhizome of Dioscorea opposita has led to the isolation of a new phenanthrene glycoside, 3,4,6-trihydroxyphenanthrene-3-O-beta-D-glucopyranoside (1), and five known compounds, soyacerebroside I (2), adenosine (3), beta-sitosterol (4), palmitic acid (5) and palmitoyloleoylphosphatidylcholine (6). Their structures were determined by spectroscopic methods, including 1D- and 2D-NMR. Compounds 1-6 exhibited no antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis.

yearjournalcountryeditionlanguage
2005-04-26Chemical and Pharmaceutical Bulletin
https://doi.org/10.1248/cpb.52.1235