6533b86dfe1ef96bd12cabee
RESEARCH PRODUCT
Development of the whisker-to-barrel cortex system.
Heiko J. LuhmannJenq-wei YangPetr UnichenkoSergei KirischukWerner KilbMaik C. Stüttgensubject
0301 basic medicineanimal structuresSensory processingBehavior AnimalGeneral NeuroscienceRepertoiremedicine.medical_treatmentCortical architectureEmbryonic StageSomatosensory CortexBarrel cortexBiology03 medical and health sciences030104 developmental biology0302 clinical medicinemedicine.anatomical_structureTouch PerceptionCortex (anatomy)VibrissaemedicineAnimalsNerve NetNeuroscience030217 neurology & neurosurgerydescription
This review provides an overview on the development of the rodent whisker-to-barrel cortex system from late embryonic stage to the end of the first postnatal month. During this period the system shows a remarkable transition from a mostly genetic-molecular driven generation of crude connectivity, providing the template for activity-dependent structural and functional maturation and plasticity, to the manifestation of a complex behavioral repertoire including social interactions. Spontaneous and sensory-evoked activity is present in neonatal barrel cortex and control the generation of the cortical architecture. Half a century after its first description by Woolsey and van der Loos the whisker-to-barrel cortex system with its unique and clear topographic organization still offers the exceptional opportunity to study sensory processing and complex behavior.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-12-01 | Current opinion in neurobiology |