6533b86efe1ef96bd12cb277

RESEARCH PRODUCT

Solubility of quercetin in supercritical CO2 + ethanol as a modifier: measurements and thermodynamic modelling

Tiziana FornariAngel BernaRoumiana P. StatevaAmparo Cháfer

subject

EthanolAntioxidantSolid solubilityChemistryGeneral Chemical Engineeringmedicine.medical_treatmentCondensed Matter PhysicsSupercritical fluidchemistry.chemical_compoundCarbon dioxidemedicineOrganic chemistryPhysical and Theoretical ChemistrySolubilityQuercetin

description

Abstract Grape seeds extracts have shown a broad range of pharmacological activities including, among others, antiulcer and antioxidant properties, which are mainly attributed to the phenolic compounds present. To date, the most abundant phenolic compounds isolated from grape seeds are catechins and their derivatives, e.g. quercetin. The present study is devoted to the experimental measurement and thermodynamic modelling of the solubility of quercetin in supercritical CO 2 + ethanol as a co-solvent. The solubility of quercetin was measured at 313.15 K, pressures ranging from 80 to 120 bar, and at different content of the modifier ethanol—from 5 to 30%. Two types of thermodynamic models were applied to model the solubility of quercetin—the group contribution equation of state (GC-EoS), developed by Skjold–Jogensen, and the Soave–Redlich–Kwong (SRK) EoS.

yearjournalcountryeditionlanguage
2004-12-01The Journal of Supercritical Fluids
https://doi.org/10.1016/j.supflu.2004.02.005