6533b86efe1ef96bd12cb4ce
RESEARCH PRODUCT
Binding equilibria between beta-cyclodextrin and p-nitro-aniline derivatives: the first systematic study in mixed water-methanol solvent systems.
Renato NotoFrancesca D'annaMichelangelo GruttadauriaPaolo Lo MeoSerena Rielasubject
chemistry.chemical_classificationCyclodextrinOrganic ChemistryEnthalpyNitro compoundSettore CHIM/06 - Chimica OrganicaBiochemistryCyclodextrin host-guest complexes polarimetryInclusion compoundSolventchemistry.chemical_compoundAnilinechemistryComputational chemistryDrug DiscoveryNitroMoleculeOrganic chemistrydescription
Abstract Complexation equilibria, in mixed water–methanol solvent media, between native β-cyclodextrin and a set of suitably selected p -nitro-aniline derivatives were studied by means of polarimetry. The effects exerted by the organic co-solvent on the conditional inclusion free energies Δ G cond 0 and the differential molar optical rotations Δ Θ were thoroughly analyzed under the perspective of the enthalpy–entropy compensation effect. Experimental data suggest an intimate participation (‘dynamic co-inclusion’) of solvent molecules in the formation and in the conformational dynamics of the host–guest inclusion complex.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-03-01 |