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RESEARCH PRODUCT
Erythrocyte deformability evaluated by laser diffractometry in polycythemia vera.
Maria MontanaBarone RitaClementina CaraccioloGregorio CaimiAnna CataniaRosalia Lo Prestisubject
AdultMalemedicine.medical_specialtyPhysiologyMyeloproliferative diseasePolycythemia veraPhysiology (medical)Internal medicineErythrocyte DeformabilityHyperviscosity syndromemedicineErythrocyte deformabilityHumansPolycythemia VeraAgedRed CellChemistryLasersHematologyMiddle Agedmedicine.diseaseSurgeryEndocrinologyFemaleStress MechanicalCardiology and Cardiovascular Medicinedescription
We evaluated the erythrocyte deformability in a group of subjects with polycythemia vera (PV) using a Rheodyn-SSD Laser Diffractometer, at the shear stresses of 6, 12, 30 and 60 Pa. Our data showed a significant decrease of red cell deformability, expressed as elongation index (EI), in PV subjects compared with normal controls. These results suggest that the hyperviscosity syndrome accompanying this myeloproliferative disease may be considered a mixed form, resulting from the association of a polycythemic condition with a sclerocythemic disorder.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-01-14 | Clinical hemorheology and microcirculation |