6533b86efe1ef96bd12cb63e

RESEARCH PRODUCT

Synthetic antitumor vaccines containing MUC1 glycopeptides with two immunodominant domains-induction of a strong immune response against breast tumor tissues.

Edgar SchmittBastian GerlitzkiHorst KunzNikola GaidzikUlrika WesterlindHans-peter SinnAnton KaiserDanuta Kowalczyk

subject

Molecular ConformationAntineoplastic AgentsBreast Neoplasmscomplex mixturesCancer VaccinesCatalysisBreast tumorMiceImmune systemmedicineAnimalsMUC1Mice Inbred BALB CVaccines SyntheticbiologyTetanusChemistryMucin-1ToxoidGlycopeptidesMammary Neoplasms ExperimentalGeneral Chemistrymedicine.diseaseGlycopeptideCancer researchbiology.proteinMCF-7 CellsExperimental pathologyFemaleAntibodyDrug Screening Assays Antitumor

description

A shot in the arm for cancer treatment: two MUC1 tetanus toxoid vaccines were synthesized and induced a strong immune response in mice. The antibodies elicited by the vaccines show a high selectivity for the tumor cells in mammary carcinoma tissues and also distinguish between tumor tissues at different stages.

yearjournalcountryeditionlanguage
2011-06-30Angewandte Chemie (International ed. in English)
10.1002/anie.201104529https://pubmed.ncbi.nlm.nih.gov/21910197