6533b86efe1ef96bd12cb67b

RESEARCH PRODUCT

Sarcomatoid carcinoma of urinary bladder: Immunohistochemical study of an uncommon case

Vincenzo SerrettaF AragonaGiuseppe RandazzoD. MelloniFrancesco Cappello

subject

Pathologymedicine.medical_specialtyUrinary bladder tumorAE1/AE3 cytokeratinmedicine.medical_treatmentUrologyVimentinSarcomatoid carcinomaCystectomyCytokeratinBiopsyHumansMedicineSarcomatoid carcinomaAgedUrinary bladderbiologymedicine.diagnostic_testAE1/AE3 cytokeratins; Human pancytokeratin; Sarcomatoid carcinoma; Urinary bladder tumors; Urologybusiness.industryCarcinomaSarcomamedicine.diseaseImmunohistochemistrymedicine.anatomical_structureUrinary Bladder NeoplasmsHuman pancytokeratinbiology.proteinKeratinsFemaleSarcomabusinessSpindle cell carcinoma

description

A case of sarcomatoid carcinoma of the bladder is reported herein. Immunohistochemical staining with human pancytokeratin antibody was negative, while vimentin staining was strongly positive, suggesting a diagnosis of sarcoma of the bladder. Further immunohistochemical analysis revealed positivity for AE1/AE3 cytokeratins, permitting a correct diagnosis of sarcomatoid carcinoma of the bladder. It can be difficult to distinguish between sarcomatoid carcinoma, undifferentiated carcinoma and sarcoma, particularly if the biopsy specimens are of small size. In rare cases, sarcomatoid tumors may express epithelial markers different from those revealed by human pancytokeratin staining. Copyright © 2002 S. Karger AG, Basel.

yearjournalcountryeditionlanguage
2002-08-21
10.1159/000065564http://hdl.handle.net/10447/198480