6533b86efe1ef96bd12cbcf2

RESEARCH PRODUCT

Cytometric analysis of oral scrapings of patients with oral lichen planus

Amelia Acha-sagredoJose V. BaganMaría Angeles Echebarría-goicouríaY. JiménezJosé-manuel Aguirre-urizar

subject

Pathologymedicine.medical_specialtyeducation.field_of_studyHistologyintegumentary systembusiness.industryPopulationAneuploidyDna indexGeneral Medicinemedicine.diseasePathology and Forensic Medicinestomatognathic diseasesstomatognathic systemmedicineOral lichen planusskin and connective tissue diseasesbusinesseducationDNA Image Cytometry

description

A. Acha-Sagredo, Y. Jimenez, J. V. Bagan, M. A. Echebarria-Goicouria and J. M. Aguirre-Utric analysis of oral scrapings of patients with oral lichen planus Objective:  Aneuploidy has been associated with malignant and premalignant oral lesions. In the past few years, its application in oral precancerous lesions and its prognostic meaning have been controversial issues. The aim of our study was to characterize alterations in DNA content by automated DNA image cytometry in oral scrapings of patients with oral lichen planus. Methods:  Cytological samples from 40 patients clinicopathologically diagnosed with oral lichen planus were analysed by DNA image cytometry. Results:  All the cases were classified as diploid, showing a predominant population of cells with normal DNA content (DNA index, 0.85–1.15). Atrophic/erosive lesions showed a higher percentage of tetraploid cells when compared with reticular/papular lesions but this was not statistically significant (P = 0.09). Conclusions:  Aneuploidy does not seem a common event in oral lichen planus lesions. However, we consider that the use of DNA image cytometry of oral scrapings may be an easy and helpful methodology in the follow-up of patients with these lesions.

yearjournalcountryeditionlanguage
2011-03-23Cytopathology
https://doi.org/10.1111/j.1365-2303.2010.00763.x