6533b86efe1ef96bd12cbdda

RESEARCH PRODUCT

Long-term use of human albumin for the treatment of ascites in patients with hepatic cirrhosis: The interim analysis of the ANSWER study

Stefano FagiuoliAnnalisa TortoraGianluca Svegliati-baroniAlida AndrealliIrene CacciolaRaffaele CozzolongoMaria Assunta ZoccoFrancesco SalernoM. ZappimbulsoM. CavallinF. De LeonardisA. MarinChiara EliaSergio NeriPaolo CaraceniFabio Salvatore MacalusoA. RoncadoriArianna LanziF. LevantesiElga NeriGiacomo ZaccheriniD. MaiorcaGianfranco EliaLucia CesariniF. FidoneS. BocciaFilomena MoriscoFabio PuglieseAldo AiroldiVincenzo SangiovanniOliviero RiggioSara MassironiL. SimoneR. De MarcoG. MaginiPierluigi ToniuttoManuel TufoniSalvatore PianoA AlbertiFrancesco Giuseppe FoschiChiara PasqualeGiovanni ParrellaGiacomo LaffiPaolo AngeliSilvia NardelliMarco MarzioniAlessandro FedericoG. ButeraRiccardo GuariscoMauro BernardiCarlo AlessandriaAntonio MastroianniRoberto Giulio Romanelli

subject

medicine.medical_specialtyCirrhosisHepatologybusiness.industryGastroenterologymedicine.diseaseInterim analysisGastroenterologyLiver diseaseInternal medicineCohortAscitesmedicineEtiologyLiver functionStage (cooking)medicine.symptombusiness

description

s / Digestive and Liver Disease 47S (2015) e1–e18 e7 (months; 95% CI): CPT 0 62 (52.9–71.1), A 44 (41.6–46.4), B 22 (19.7–24.3), C 9 (6.6–11.3), p<0.0001. Comparisons between survivals of CTP 0 vs A, B and C were also statistically different (p<0.0001 in all associations). The prognosis of patients in the intermediateBCLCstagealsodifferedaccording to the liver function (0 vs A vs B, p<0.0001). Conclusions: The newly proposed CTP class 0 identifies a different subgroup of patientswith a better prognosis, alsowhen applied in a European cohort, where HCV aetiology is predominant. This new approach impacts not only on outcome prediction but also, potentially, on treatment allocation, better stratifying, in particular, the heterogeneous intermediate BCLC-B stage. http://dx.doi.org/10.1016/j.dld.2015.01.018

yearjournalcountryeditionlanguage
2015-02-01Digestive and Liver Disease
https://doi.org/10.1016/j.dld.2015.01.017