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RESEARCH PRODUCT
Induction of pyroptosis in colon cancer cells by LXRβ.
Cédric RébéValentin DerangèreFrançois Ghiringhellisubject
Gene isoformAgonistCancer ResearchChemistryColorectal cancermedicine.drug_classpyroptosisCaspase 1PyroptosisNLRP3 pannexin 1medicine.diseaseIn vitro3. Good healthCell biologycolon cancerIn vivoCaspase-1medicineMolecular MedicineLXRLiver X receptorAuthor's Viewdescription
Liver X receptors (LXRs) have been proposed to have some anticancer properties. We recently identified a new non-genomic role of LXRβ in colon cancer cells. Under LXR agonist treatment, LXRβ induces pyroptosis of these cells in vitro and in vivo, raising the possibility of targeting this isoform in cancer treatment.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-09-09 | Molecularcellular oncology |