6533b86efe1ef96bd12cc6d3
RESEARCH PRODUCT
The chemistry of [1,2,3]triazolo[1,5- c ]pyrimidine
Belén AbarcaJavier MirallesDimas ColonnaJosé Vicente MurilloRafael BallesterosMimoun Chadlaouisubject
chemistry.chemical_compoundNucleophilechemistryPyrimidineStrong acidsStereochemistryOrganic ChemistryDrug DiscoveryElectrophileTriazoleProtonationRing (chemistry)Biochemistrydescription
Abstract Reactions of [1,2,3]triazolo[1,5-c]pyrimidine 2 with some electrophiles and nucleophiles are reported. Triazole ring opening and loss of nitrogen is the principal reaction with electrophiles. With strong acids protonation on N6 competes successfully. Derivatives in which the pyrimidine ring has been opened are obtained in reactions with nucleophiles. No stable simple substitution compounds were found.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-12-01 | Tetrahedron |