Improvement of analytical methods in post‐market monitoring of food additives and testing of the improved methods (OC/EFSA/DCM/2012/04): Interim report on method development and in‐house validation of the analysis method

The chemistry of [1,2,3]triazolo[1,5- c ]pyrimidine

Abstract Reactions of [1,2,3]triazolo[1,5-c]pyrimidine 2 with some electrophiles and nucleophiles are reported. Triazole ring opening and loss of nitrogen is the principal reaction with electrophiles. With strong acids protonation on N6 competes successfully. Derivatives in which the pyrimidine ring has been opened are obtained in reactions with nucleophiles. No stable simple substitution compounds were found.