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RESEARCH PRODUCT
DNA-Based Enzyme Reactors and Systems
J. Jussi ToppariKosti TapioLaura AarnosS. NummelinMauri A. KostiainenVeikko Linkosubject
DNA sensorsGeneral Chemical EngineeringeducationNanotechnologyDNA nanodevice02 engineering and technologyReviewBiology010402 general chemistry01 natural scienceslcsh:Chemistrychemistry.chemical_compoundDna nanostructuresDNA nanotechnologyDNA origamiGeneral Materials ScienceDNA nanotechnologychemistry.chemical_classificationPhysicsfood and beveragesself-assemblycascade reactions021001 nanoscience & nanotechnologyBiocompatible materialnanolääketiedenanomedicineDrug-deliveryMaterials science0104 chemical sciencesdrug-deliveryChemistryenzymeEnzymechemistrylcsh:QD1-999drug deliveryNanomedicineDNA origami0210 nano-technologyDNABiotechnologydescription
During recent years, the possibility to create custom biocompatible nanoshapes using DNA as a building material has rapidly emerged. Further, these rationally designed DNA structures could be exploited in positioning pivotal molecules, such as enzymes, with nanometer-level precision. This feature could be used in the fabrication of artificial biochemical machinery that is able to mimic the complex reactions found in living cells. Currently, DNA-enzyme hybrids can be used to control (multi-enzyme) cascade reactions and to regulate the enzyme functions and the reaction pathways. Moreover, sophisticated DNA structures can be utilized in encapsulating active enzymes and delivering the molecular cargo into cells. In this review, we focus on the latest enzyme systems based on novel DNA nanostructures: enzyme reactors, regulatory devices and carriers that can find uses in various biotechnological and nanomedical applications. Peer reviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-07-01 | Nanomaterials |