6533b86efe1ef96bd12cc9ff

RESEARCH PRODUCT

Antimicrobial and antiproliferative activity of Peucedanum nebrodense (Guss.) Strohl.

Fabiana PlesciaDomenico SchillaciFabio VenturellaF. Venuti

subject

Antineoplastic AgentsHL-60 CellsBiologyPlant RootsAcetoneMiceAnti-Infective Agentshemic and lymphatic diseasesDrug DiscoverymedicinePeucedanum nebrodenseCoumarins Antimicrobial Antiproliferative activityAnimalsHumansLeukemia L1210PharmacologyTraditional medicinePlant ExtractsBiological activityPlant Components AerialAntimicrobialmedicine.diseaseIn vitroLeukemiaCell cultureK562 CellsPeucedanum nebrodenseCell DivisionChronic myelogenous leukemiaK562 cellsApiaceae

description

Abstract Acetone extract of Peucedanum nebrodense (Guss.) Strohl., a rare endemic species from the Madonie mountains (Sicily), was tested in vitro for its antimicrobial activity against bacterial reference strains and antiproliferative activity against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and L1210 (murine leukemia) cell lines. The acetone extract showed antiproliferative IC 50 values in the range of 14–0.27 μg/ml.

yearjournalcountryeditionlanguage
2003-07-01Journal of ethnopharmacology
10.1016/s0378-8741(03)00116-8https://pubmed.ncbi.nlm.nih.gov/12787961