6533b86ffe1ef96bd12cd447

RESEARCH PRODUCT

Daptomycin for children in clinical practice experience

Silvia GarazzinoElio CastagnolaMaria Di GangiRita OrtolanoAndrzej KrzysztofiakAgostino NocerinoSusanna EspositoPatrizia D'argenioLuisa GalliGiuseppe LosurdoCarmelina CalitriPier Angelo TovoRoberto For The Sitip Daptomycin Study Group Including BandettiniSalvatore GiordanoPiera DonesOttavio ZiinoClara MosaMargherita RobazzaClaudia TagliabueLaura LancellaFrancesca Carraro

subject

Male0301 basic medicinePediatricsmedicine.disease_causePediatrics0302 clinical medicinepolycyclic compounds030212 general & internal medicineChildChildrenMedicine (all)OsteomyelitisBacterial InfectionsPerinatology and Child HealthAnti-Bacterial AgentsClinical PracticeInfectious DiseasesChild PreschoolAdministration IntravenousFemalelipids (amino acids peptides and proteins)Children; Daptomycin; Methicillin-resistant Staphylococcus aureus; Osteomyelitis; Sepsis; Pediatrics Perinatology and Child Health; Medicine (all); Microbiology (medical); Infectious DiseasesMethicillin-resistant Staphylococcus aureusmedicine.drugMicrobiology (medical)medicine.medical_specialtyAdolescentDrug-Related Side Effects and Adverse Reactions030106 microbiologyChildren; Daptomycin; Methicillin-resistant Staphylococcus aureus; Osteomyelitis; Sepsis;Sepsis03 medical and health sciencesDaptomycinSepsismedicineHumansAdverse effectRetrospective Studiesbusiness.industryOsteomyelitisInfant NewbornInfantRetrospective cohort studybiochemical phenomena metabolism and nutritionbacterial infections and mycosesmedicine.diseaseMethicillin-resistant Staphylococcus aureuscarbohydrates (lipids)Pediatrics Perinatology and Child HealthDaptomycinbusinessProlonged treatment

description

Data on daptomycin use in the pediatric setting are scanty. We conducted a multicenter, retrospective study on 46 children treated with intravenous daptomycin at a mean dosage of 7.0 mg/kg/d, for a median of 14 days. Three children had adverse events possibly related to daptomycin. The drug was overall well tolerated, even with prolonged treatment.

yearjournalcountryeditionlanguage
2016-01-01
10.1097/inf.0000000000001121http://hdl.handle.net/2318/1594194