6533b86ffe1ef96bd12cdc43
RESEARCH PRODUCT
Phytochemistry of Weigela x “kosteriana variegata” (Caprifoliaceae)
Chiaki TanakaMarie Aleth Lacaille-duboisBenoist PruvotTomofumi MiyamotoAnne Claire Mitaine-offerNampoina AndriamisainaJohanna Chlubasubject
Pharmacologychemistry.chemical_classificationWeigelaPhytochemistrybiology010405 organic chemistryStereochemistryGlycosidePlant ScienceGeneral MedicineCarbon-13 NMRbiology.organism_classification01 natural sciences0104 chemical sciences010404 medicinal & biomolecular chemistryComplementary and alternative medicineTriterpenechemistryDrug DiscoveryCaprifoliaceaeTwo-dimensional nuclear magnetic resonance spectroscopyHeteronuclear single quantum coherence spectroscopydescription
One new triterpene glycoside 3- O-β-D-xylopyranosyl-(1→4)-[β-D-glucopyranosyl-(1→3)]-β-D-xylopyranosyl-(1→4)-β-D-xylopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyloleanolic acid, was isolated from Weigela x “kosteriana variegata” (Caprifoliaceae), with three known ones. Their structures were characterized by a combination of mass spectrometry and 1D and 2D NMR spectrocopic techniques including 1H- and 13C NMR, COSY, TOCSY, NOESY, HSQC, and HMBC experiments. The toxicological properties of some glycosides were determined with a zebrafish-based assay. The results show that the most active compounds were toxic to the larvae in the range of 1 μM.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-04-01 | Natural Product Communications |