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RESEARCH PRODUCT

An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry.

S. ReglioniC. BilardiPatrizia ZentilinAndrea ParodiVincenzo SavarinoSergio VigneriElena IiritanoEdoardo SavarinoPietro Dulbecco

subject

Novel techniqueAdultMalemedicine.medical_specialtySYMPTOMATIC TREATMENTACID REFLUXAlginatesSymptomatic treatmentSilicic AcidUrologySupine decubitusGASTROESOPHAGEAL-REFLUX DISEASEAluminum HydroxideGastric AcidPh metrymedicineHumansPharmacology (medical)Sodium alginateGASTROESOPHAGEAL-REFLUX DISEASE; SYMPTOMATIC TREATMENT; ACID REFLUXAgedHepatologybusiness.industrydigestive oral and skin physiologyGastroenterologyRefluxHydrogen-Ion ConcentrationMiddle Ageddigestive system diseasesSurgeryClinical PracticeDrug CombinationsSodium BicarbonateGastroesophageal RefluxDrug EvaluationFemaleAntacidsbusiness

description

Summary Background : Alginate-based preparations act as mechanical antireflux barrier, which can reduce both acid and non-acid reflux events and limit the proximal migration of oesophageal refluxate. Aim : To evaluate all the above features with a novel technique, multichannel electrical impedance and pH-metry. Methods : Ten reflux patients underwent stationary impedancemetry and pH-metry after eating a refluxogenic meal. They were studied 1 h in basal conditions and 1 h after taking 10 mL of Gaviscon Advance. In both sessions, measurements were obtained in right lateral and supine decubitus. Results : Alginate preparation was able to decrease significantly (P < 0.05) the number of acid reflux events and the percentage time pH < 4.0 compared with baseline. There was no effect of the drug on non-acid refluxes. Gaviscon Advance was also significantly effective (P < 0.05) in reducing the height of proximal migration of reflux events compared with baseline in both decubitus positions. Conclusions : Our findings explain how Gaviscon Advance controls acid reflux episodes, limits the proximal migration of refluxed material and thereby decreases symptoms in clinical practice.

yearjournalcountryeditionlanguage
2005-01-13Alimentary pharmacologytherapeutics
10.1111/j.1365-2036.2004.02298.xhttps://pubmed.ncbi.nlm.nih.gov/15644042